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β1a490–508, a 19-Residue Peptide from C-Terminal Tail of Cav1.1 β1a Subunit, Potentiates Voltage-Dependent Calcium Release in Adult Skeletal Muscle Fibers

Hernández-Ochoa, Erick O.; Olojo, Rotimi O.; Rebbeck, Robyn T.; Dulhunty, Angela F.; Schneider, Martin F.


The α1 and β1a subunits of the skeletal muscle calcium channel, Cav1.1, as well as the Ca(2+) release channel, ryanodine receptor (RyR1), are essential for excitation-contraction coupling. RyR1 channel activity is modulated by the β1a subunit and this effect can be mimicked by a peptide (β1a490-524) corresponding to the 35-residue C-terminal tail of the β1a subunit. Protein-protein interaction assays confirmed a high-affinity interaction between the C-terminal tail of the β1a and RyR1. Based on...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Biophysical Journal
DOI: 10.1016/j.bpj.2013.11.4503


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