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A comparative study of the quality of DNA obtained from fresh frozen and formalin-fixed decalcified paraffin-embedded bone marrow trephine biopsy specimens using two different methods

Talaulikar, Dipti; Gray, J X; Shadbolt, Bruce; McNiven, M; Dahlstrom, Jane

Description

BACKGROUND Given its prognostic value, there is renewed interest in molecular staging in non-Hodgkin's lymphoma (NHL) using immunoglobulin heavy and light chain (IgH, IgL) gene rearrangements. AIMS To compare the efficiency of DNA amplification from fresh frozen and formalin-fixed decalcified paraffin-embedded (FFDPE) bone marrow trephines for use in molecular staging using two methods. METHODS After manually extracting DNA from 13 FFDPE and 14 fresh frozen trephine biopsy specimens, two...[Show more]

CollectionsANU Research Publications
Date published: 2007-06-01
Type: Journal article
URI: http://hdl.handle.net/1885/100963
Source: Journal of Clinical Pathology
DOI: 10.1136/jcp.2006.045294

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