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Conduction of Na+ and K+ through the NaK Channel: Molecular and Brownian Dynamics Studies

Vora, Taira; Bisset, David; Chung, Shin-Ho


Conduction of ions through the NaK channel, with M0 helix removed, was studied using both Brownian dynamics and molecular dynamics. Brownian dynamics simulations predict that the truncated NaK has approximately a third of the conductance of the related KcsA K+ channel, is outwardly rectifying, and has a Michaelis-Menten current-concentration relationship. Current magnitude increases when the glutamine residue located near the intracellular gate is replaced with a glutamate residue. The channel...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Biophysical Journal
DOI: 10.1529/biophysj.107.126722


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