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Conduction of Na+ and K+ through the NaK Channel: Molecular and Brownian Dynamics Studies

Vora, Taira; Bisset, David; Chung, Shin-Ho

Description

Conduction of ions through the NaK channel, with M0 helix removed, was studied using both Brownian dynamics and molecular dynamics. Brownian dynamics simulations predict that the truncated NaK has approximately a third of the conductance of the related KcsA K+ channel, is outwardly rectifying, and has a Michaelis-Menten current-concentration relationship. Current magnitude increases when the glutamine residue located near the intracellular gate is replaced with a glutamate residue. The channel...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
URI: http://hdl.handle.net/1885/100907
Source: Biophysical Journal
DOI: 10.1529/biophysj.107.126722

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