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Material Properties of Lipid Microdomains: Force-Volume Imaging Study of the Effect of Cholesterol on Lipid Microdomain Rigidity

An, Hongjie; Nussio, Matthew R.; Huson, Mickey G.; Voelcker, Nicolas H.; Shapter, Joseph G.


The effect of cholesterol (CHOL) on the material properties of supported lipid bilayers composed of lipid mixtures that mimic the composition of lipid microdomains was studied by force-volume (FV) imaging under near-physiological conditions. These studies were carried out with lipid mixtures of dioleoylphosphatidylcholine, dioleoylphosphatidylserine, and sphingomyelin. FV imaging enabled simultaneous topology and force measurements of sphingomyelin-rich domains (higher domain (HD)) and...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Biophysical Journal
DOI: 10.1016/j.bpj.2010.04.072


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