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Regulation of Ryanodine Receptors by Calsequestrin: Effect of High Luminal Ca2+ and Phosphorylation

Beard, Nicole A.; Casarotto, Marco G.; Wei, Lan; Varsányi, Magdolna; Laver, Derek R.; Dulhunty, Angela F.


Calsequestrin, the major calcium sequestering protein in the sarcoplasmic reticulum of muscle, forms a quaternary complex with the ryanodine receptor calcium release channel and the intrinsic membrane proteins triadin and junctin. We have investigated the possibility that calsequestrin is a luminal calcium concentration sensor for the ryanodine receptor. We measured the luminal calcium concentration at which calsequestrin dissociates from the ryanodine receptor and the effect of calsequestrin...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Biophysical Journal
DOI: 10.1529/biophysj.104.051441


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