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The Interaction of αB-Crystallin with Mature α-Synuclein Amyloid Fibrils Inhibits Their Elongation

Waudby, Christopher A.; Knowles, Tuomas P.J.; Devlin, Glyn L.; Skepper, Jeremy N.; Ecroyd, Heath; Carver, John A.; Welland, Mark E.; Christodoulou, John; Dobson, Christopher M.; Meehan, Sarah

Description

alphaB-Crystallin is a small heat-shock protein (sHsp) that is colocalized with alpha-synuclein (alphaSyn) in Lewy bodies-the pathological hallmarks of Parkinson's disease-and is an inhibitor of alphaSyn amyloid fibril formation in an ATP-independent manner in vitro. We have investigated the mechanism underlying the inhibitory action of sHsps, and here we establish, by means of a variety of biophysical techniques including immunogold labeling and nuclear magnetic resonance spectroscopy, that...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
URI: http://hdl.handle.net/1885/100881
Source: Biophysical Journal
DOI: 10.1016/j.bpj.2009.10.056

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