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Homology Model of the GABAA Receptor Examined Using Brownian Dynamics

O’Mara, Megan; Cromer, Brett; Parker, Michael; Chung, Shin-Ho


We have developed a homology model of the GABAA receptor, using the subunit combination of α1β2γ2, the most prevalent type in the mammalian brain. The model is produced in two parts: the membrane-embedded channel domain and the extracellular N-terminal domain. The pentameric transmembrane domain model is built by modeling each subunit by homology with the equivalent subunit of the heteropentameric acetylcholine receptor transmembrane domain. This segment is then joined with the extracellular...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Biophysical Journal
DOI: 10.1529/biophysj.104.051664


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