Skip navigation
Skip navigation

Molecular Dynamics Simulations of Scorpion Toxin Recognition by the Ca²⁺-Activated Potassium Channel KCa3.1

Chen, Rong; Chung, Shin-Ho

Description

The Ca²⁺-activated channel of intermediate-conductance (KCa3.1) is a target for antisickling and immunosuppressant agents. Many small peptides isolated from animal venoms inhibit KCa3.1 with nanomolar affinities and are promising drug scaffolds. Although the inhibitory effect of peptide toxins on KCa3.1 has been examined extensively, the structural basis of toxin-channel recognition has not been understood in detail. Here, the binding modes of two selected scorpion toxins, charybdotoxin (ChTx)...[Show more]

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
URI: http://hdl.handle.net/1885/100864
Source: Biophysical Journal
DOI: 10.1016/j.bpj.2013.08.046

Download

File Description SizeFormat Image
01_Chen_Molecular_Dynamics_Simulations_2013.pdf654.81 kBAdobe PDFThumbnail


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  23 August 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator