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uPEPperoni: An online tool for upstream open reading frame location and analysis of transcript conservation

Skarshewski, Adam; Stanton-Cook, Mitchell; Al Mansoori, Sumaya; Smith, Ross; Beatson, Scott A; Rothnagel, Joseph A; Huber, Thomas


BACKGROUND Several small open reading frames located within the 5' untranslated regions of mRNAs have recently been shown to be translated. In humans, about 50% of mRNAs contain at least one upstream open reading frame representing a large resource of coding potential. We propose that some upstream open reading frames encode peptides that are functional and contribute to proteome complexity in humans and other organisms. We use the term uPEPs to describe peptides encoded by upstream open...[Show more]

CollectionsANU Research Publications
Date published: 2014-02-01
Type: Journal article
Source: BMC Bioinformatics
DOI: 10.1186/1471-2105-15-36
Access Rights: Open Access


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