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QTLRel: an R Package for Genome-wide Association Studies in which Relatedness is a Concern

Cheng, Riyan; Abney, Mark; Palmer, Abraham A; Skol, Andrew D

Description

BACKGROUND Existing software for quantitative trait mapping is either not able to model polygenic variation or does not allow incorporation of more than one genetic variance component. Improperly modeling the genetic relatedness among subjects can result in excessive false positives. We have developed an R package, QTLRel, to enable more flexible modeling of genetic relatedness as well as covariates and non-genetic variance components. RESULTS We have successfully used the package to analyze...[Show more]

CollectionsANU Research Publications
Date published: 2011-07-27
Type: Journal article
URI: http://hdl.handle.net/1885/100858
Source: BMC Genetics
DOI: 10.1186/1471-2156-12-66

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