Skip navigation
Skip navigation

Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8⁺ cell–dependent mechanism

Wong, Kenneth K.; Carpenter, Matthew J.; Young, Lesley L.; Walker, Susan J.; McKenzie, Grahame; Rust, Alyson J.; Ward, George; Packwood, Laura; Wahl, Karen; Delriviere, Luc; Hoyne, Gerard; Gibbs, Paul; Champion, Brian R.; Lamb, Jonathan R.; Dallman, Margaret J.


Notch signaling plays a fundamental role in determining the outcome of differentiation processes in many tissues. Notch signaling has been implicated in T versus B cell lineage commitment, thymic differentiation, and bone marrow hematopoietic precursor renewal and differentiation. Notch receptors and their ligands are also expressed on the surface of mature lymphocytes and APCs, but the effects of Notch signaling in the peripheral immune system remain poorly defined. The aim of the studies...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Journal of Clinical Investigation
DOI: 10.1172/JCI200318020
Access Rights: Open Access


File Description SizeFormat Image
01_Wong_Notch_ligation_by_Delta1_2003.pdfPublished Version776.24 kBAdobe PDFThumbnail

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator