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Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8⁺ cell–dependent mechanism

Wong, Kenneth K.; Carpenter, Matthew J.; Young, Lesley L.; Walker, Susan J.; McKenzie, Grahame; Rust, Alyson J.; Ward, George; Packwood, Laura; Wahl, Karen; Delriviere, Luc; Hoyne, Gerard; Gibbs, Paul; Champion, Brian R.; Lamb, Jonathan R.; Dallman, Margaret J.


Notch signaling plays a fundamental role in determining the outcome of differentiation processes in many tissues. Notch signaling has been implicated in T versus B cell lineage commitment, thymic differentiation, and bone marrow hematopoietic precursor renewal and differentiation. Notch receptors and their ligands are also expressed on the surface of mature lymphocytes and APCs, but the effects of Notch signaling in the peripheral immune system remain poorly defined. The aim of the studies...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Journal of Clinical Investigation
DOI: 10.1172/JCI200318020


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