Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8⁺ cell–dependent mechanism
Wong, Kenneth K.; Carpenter, Matthew J.; Young, Lesley L.; Walker, Susan J.; McKenzie, Grahame; Rust, Alyson J.; Ward, George; Packwood, Laura; Wahl, Karen; Delriviere, Luc; Hoyne, Gerard; Gibbs, Paul; Champion, Brian R.; Lamb, Jonathan R.; Dallman, Margaret J.
Notch signaling plays a fundamental role in determining the outcome of differentiation processes in many tissues. Notch signaling has been implicated in T versus B cell lineage commitment, thymic differentiation, and bone marrow hematopoietic precursor renewal and differentiation. Notch receptors and their ligands are also expressed on the surface of mature lymphocytes and APCs, but the effects of Notch signaling in the peripheral immune system remain poorly defined. The aim of the studies...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Clinical Investigation|
|01_Wong_Notch_ligation_by_Delta1_2003.pdf||Published Version||776.24 kB||Adobe PDF|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.