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BAFF selectively enhances the survival of plasmablasts generated from human memory B cells

Avery, Danielle T.; Kalled, Susan L.; Ellyard, Julia I.; Ambrose, Christine; Bixler, Sarah A.; Thien, Marilyn; Brink, Robert; Mackay, Fabienne; Hodgkin, Philip D.; Tangye, Stuart G.

Description

The generation of Ig-secreting cells (ISCs) from memory B cells requires interactions between antigen-specific (Ag-specific) B cells, T cells, and dendritic cells. This process must be strictly regulated to ensure sufficient humoral immunity while avoiding production of pathogenic autoantibodies. BAFF, a member of the TNF family, is a key regulator of B cell homeostasis. BAFF exerts its effect by binding to three receptors — transmembrane activator of and CAML interactor (TACI), B cell...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
URI: http://hdl.handle.net/1885/100838
Source: Journal of Clinical Investigation
DOI: 10.1172/JCI18025

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