BAFF selectively enhances the survival of plasmablasts generated from human memory B cells
The generation of Ig-secreting cells (ISCs) from memory B cells requires interactions between antigen-specific (Ag-specific) B cells, T cells, and dendritic cells. This process must be strictly regulated to ensure sufficient humoral immunity while avoiding production of pathogenic autoantibodies. BAFF, a member of the TNF family, is a key regulator of B cell homeostasis. BAFF exerts its effect by binding to three receptors — transmembrane activator of and CAML interactor (TACI), B cell...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Clinical Investigation|
|01_Avery_BAFF_selectively_enhances_the_2003.pdf||Published Version||1.15 MB||Adobe PDF|
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