The Unfolded Protein Response Transducer Ire1p Contains a Nuclear Localization Sequence Recognized by Multiple β Importins
The Ire1p transmembrane receptor kinase/endonuclease transduces the unfolded protein response (UPR) from the endoplasmic reticulum (ER) to the nucleus in Saccharomyces cerevisiae. In this study, we analyzed the capacity of a highly basic sequence in the linker region of Ire1p to function as a nuclear localization sequence (NLS) both in vivo and in vitro. This 18-residue sequence is capable of targeting green fluorescent protein to the nucleus of yeast cells in a process requiring proteins...[Show more]
|Collections||ANU Research Publications|
|Source:||Molecular Biology of the Cell|
|Access Rights:||Open Access|
|01_Goffin_The_Unfolded_Protein_Response_2006.pdf||Published Version||2.62 MB||Adobe PDF|
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