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The Unfolded Protein Response Transducer Ire1p Contains a Nuclear Localization Sequence Recognized by Multiple β Importins

Goffin, L.; Vodala, S.; Fraser, Christine; Ryan, J.; Timms, M.; Meusburger, S.; Catimel, B.; Nice, E. C.; Silver, P. A.; Xiao, C.-Y.; Jans, D. A.; Gething, M.-J. H.


The Ire1p transmembrane receptor kinase/endonuclease transduces the unfolded protein response (UPR) from the endoplasmic reticulum (ER) to the nucleus in Saccharomyces cerevisiae. In this study, we analyzed the capacity of a highly basic sequence in the linker region of Ire1p to function as a nuclear localization sequence (NLS) both in vivo and in vitro. This 18-residue sequence is capable of targeting green fluorescent protein to the nucleus of yeast cells in a process requiring proteins...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Molecular Biology of the Cell
DOI: 10.1091/mbc.E06-04-0292
Access Rights: Open Access


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