The Unfolded Protein Response Transducer Ire1p Contains a Nuclear Localization Sequence Recognized by Multiple β Importins
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Goffin, L.; Vodala, S.; Fraser, Christine; Ryan, J.; Timms, M.; Meusburger, S.; Catimel, B.; Nice, E. C.; Silver, P. A.; Xiao, C.-Y.; Jans, D. A.; Gething, M.-J. H.
Description
The Ire1p transmembrane receptor kinase/endonuclease transduces the unfolded protein response (UPR) from the endoplasmic reticulum (ER) to the nucleus in Saccharomyces cerevisiae. In this study, we analyzed the capacity of a highly basic sequence in the linker region of Ire1p to function as a nuclear localization sequence (NLS) both in vivo and in vitro. This 18-residue sequence is capable of targeting green fluorescent protein to the nucleus of yeast cells in a process requiring proteins...[Show more]
Collections | ANU Research Publications |
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Date published: | 2006 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/100836 |
Source: | Molecular Biology of the Cell |
DOI: | 10.1091/mbc.E06-04-0292 |
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01_Goffin_The_Unfolded_Protein_Response_2006.pdf | Published Version | 2.62 MB | Adobe PDF | ![]() |
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