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An autocrine TGF- /ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition

Gregory, P. A.; Bracken, C. P.; Smith, E.; Bert, A. G.; Wright, J. A.; Roslan, S.; Morris, M.; Wyatt, L.; Farshid, G.; Lim, Y.-Y.; Lindeman, G. J.; Shannon, M. F.; Drew, P. A.; Khew-Goodall, Y.; Goodall, G. J.


Epithelial-mesenchymal transition (EMT) is a form of cellular plasticity that is critical for embryonic development and tumor metastasis. A double-negative feedback loop involving the miR-200 family and ZEB (zinc finger E-box-binding homeobox) transcription factors has been postulated to control the balance between epithelial and mesenchymal states. Here we demonstrate using the epithelial Madin Darby canine kidney cell line model that, although manipulation of the ZEB/miR-200 balance is able...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Molecular Biology of the Cell
DOI: 10.1091/mbc.E11-02-0103


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