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Angiogenic growth factors are new and essential players in the sustained relaxin vasodilatory pathway in rodents and humans

McGuane, Jonathan T.; Danielson, Leslie A.; Debrah, Julianna E.; Rubin, J. Peter; Novak, Jacqueline; Conrad, Kirk P.

Description

Relaxin is emerging as an important vasodilator of pregnancy and is being tested for afterload reduction in acute heart failure. However, the mechanisms underlying relaxin-induced vasodilation are incompletely understood. The aims of this study were to establish a new in vitro model for relaxin-induced vasodilation and to use this approach, as well as chronically instrumented, conscious rats, to investigate the role of angiogenic growth factors in the relaxin vasodilatory pathway. Incubation of...[Show more]

CollectionsANU Research Publications
Date published: 2011-06
Type: Journal article
URI: http://hdl.handle.net/1885/100225
Source: Hypertension
DOI: 10.1161/HYPERTENSIONAHA.110.165027

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