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Relaxin induces rapid dilation of rodent small renal and human subcutaneous arteries via PI3 kinase and nitric oxide

McGuane, Jonathan T.; Debrah, Julianna E.; Sautina, Laura; Jarajapu, Yagna P. R.; Novak, Jacqueline; Rubin, J. Peter; Grant, Maria B.; Segal, Mark; Conrad, Kirk P.


The peptide hormone relaxin is a potent vasodilator with therapeutic potential in diseases complicated by vasoconstriction, including heart failure. However, the molecular mediators and magnitude of vasodilation may vary according to duration of exposure and artery type. The objective of these studies was to determine mechanisms of rapid (within minutes) relaxin-induced vasodilation and to examine whether relaxin dilates arteries from different animal species and vascular beds. Rat and mouse...[Show more]

CollectionsANU Research Publications
Date published: 2011-07
Type: Journal article
Source: Endocrinology
DOI: 10.1210/en.2010-1126


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