Skip navigation
Skip navigation

Matrix metalloproteinase-2 activity, protein, mRNA, and tissue inhibitors in small arteries from pregnant and relaxin-treated nonpregnant rats

Jeyabalan, Arundhathi; Kerchner, Laurie J.; Fisher, Michelle C.; McGuane, Jonathan T.; Doty, Ketah D.; Conrad, Kirk P.


Vascular gelatinase activity is essential for pregnancy- and relaxin (Rlx)-induced renal vasodilation and hyperfiltration in rats. The objective of this study was to further elucidate the mechanisms for the increase in vascular matrix metalloproteinase (MMP)-2 activity caused by pregnancy and Rlx. We first corroborated our earlier work by showing that pro- and active forms of MMP-2 were increased in small renal arteries from pregnant compared with virgin rats and Rlx-treated compared with...[Show more]

CollectionsANU Research Publications
Date published: 2006-06
Type: Journal article
Source: Journal of applied physiology
DOI: 10.1152/japplphysiol.01330.2005


There are no files associated with this item.

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator