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Matrix metalloproteinase-2 activity, protein, mRNA, and tissue inhibitors in small arteries from pregnant and relaxin-treated nonpregnant rats

Jeyabalan, Arundhathi; Kerchner, Laurie J; Fisher, Michelle C; McGuane, Jonathan T; Doty, Ketah D; Conrad, Kirk P

Description

Vascular gelatinase activity is essential for pregnancy- and relaxin (Rlx)-induced renal vasodilation and hyperfiltration in rats. The objective of this study was to further elucidate the mechanisms for the increase in vascular matrix metalloproteinase (MMP)-2 activity caused by pregnancy and Rlx. We first corroborated our earlier work by showing that pro- and active forms of MMP-2 were increased in small renal arteries from pregnant compared with virgin rats and Rlx-treated compared with...[Show more]

CollectionsANU Research Publications
Date published: 2006-06
Type: Journal article
URI: http://hdl.handle.net/1885/100220
Source: Journal of applied physiology
DOI: 10.1152/japplphysiol.01330.2005

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