5-Aminosalicylic acid prevents oxidant mediated damage of glyceraldehyde-3-phosphate dehydrogenase in colon epithelial cells
Background—Reactive oxygen and nitrogen derived species produced by activated neutrophils have been implicated in the damage of mucosal proteins including the inhibition of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in the active inflammatory lesion in patients with in-flammatory bowel disease (IBD). This study investigated the eYcacy of currently used IBD therapeutics to prevent injury mediated by reactive oxygen and nitrogen derived species.
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