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5-Aminosalicylic acid prevents oxidant mediated damage of glyceraldehyde-3-phosphate dehydrogenase in colon epithelial cells

McKenzie, S. M.; Doe, W. F.; Buffinton, G. D.

Description

Background—Reactive oxygen and nitrogen derived species produced by activated neutrophils have been implicated in the damage of mucosal proteins including the inhibition of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in the active inflammatory lesion in patients with in-flammatory bowel disease (IBD). This study investigated the eYcacy of currently used IBD therapeutics to prevent injury mediated by reactive oxygen and nitrogen derived species.

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
URI: http://hdl.handle.net/1885/100215
Source: Gut
DOI: 10.1136/gut.44.2.180

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