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Overlapping and distinct expression domains of Zic2 and Zic3 during mouse gastrulation

Elms, Paul; Scurry, Andrew; Davies, Jennifer; Willoughby, Catherine; Hacker, Terry; Bogani, Debora; Arkell, Ruth


The Zic genes are the vertebrate homologues of the Drosophila Odd-paired gene. Mutations in two of these genes are associated with human congenital genetic disorders. Mutation of human and mouse Zic2 is associated with holoprosencephaly which is caused by a defect of ventral forebrain development and mutation of human and mouse Zic3 is associated with a X-linked heterotaxy syndrome that results from a failure of left-right axis formation. The embryological role of the Zic genes in these...[Show more]

CollectionsANU Research Publications
Date published: 2004-09
Type: Journal article
Source: Gene Expression Patterns
DOI: 10.1016/j.modgep.2004.03.003


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