Caspase-dependent inhibition of mousepox replication by gzmB
BACKGROUND Ectromelia virus is a natural mouse pathogen, causing mousepox. The cytotoxic T (Tc) cell granule serine-protease, granzyme B, is important for its control, but the underlying mechanism is unknown. Using ex vivo virus immune Tc cells, we have previously shown that granzyme B is able to activate several independent pro-apoptotic pathways, including those mediated by Bid/Bak/Bax and caspases-3/-7, in target cells pulsed with Tc cell determinants. METHODS and FINDINGS Here we...[Show more]
|Collections||ANU Research Publications|
|Source:||PLOS ONE (Public Library of Science)|
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