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Type 2 diabetes mellitus, cognition and brain in aging: a brief review

Kumar, Rajeev; Looi, Jeffrey; Raphael, Beverley

Description

Diabetes mellitus is a complex disease with many potential complications. Whilst there have been inconsistent results in regard to an association between cognition and type 2 diabetes, there is evidence that verbal memory and processing speed are the cognitive domains usually impaired. In elderly diabetic subjects, other cognitive domains may also be involved, due to ageing. Glycemic control is implicated in the development of cognitive dysfunction, although more research is needed in this...[Show more]

dc.contributor.authorKumar, Rajeev
dc.contributor.authorLooi, Jeffrey
dc.contributor.authorRaphael, Beverley
dc.date.accessioned2009-11-02T00:28:08Z
dc.date.accessioned2010-12-20T06:03:14Z
dc.date.available2009-11-02T00:28:08Z
dc.date.available2010-12-20T06:03:14Z
dc.identifier.citationIndian Journal of Psychiatry 51 (2009): S35-8
dc.identifier.issn0019-5545
dc.identifier.issn1998-3794
dc.identifier.urihttp://hdl.handle.net/10440/986
dc.identifier.urihttp://digitalcollections.anu.edu.au/handle/10440/986
dc.description.abstractDiabetes mellitus is a complex disease with many potential complications. Whilst there have been inconsistent results in regard to an association between cognition and type 2 diabetes, there is evidence that verbal memory and processing speed are the cognitive domains usually impaired. In elderly diabetic subjects, other cognitive domains may also be involved, due to ageing. Glycemic control is implicated in the development of cognitive dysfunction, although more research is needed in this area. Insulin dysregulation and hyperglycemia play an important role in neurodegeneration. Using structural neuroimaging, it has been shown that brain atrophy is an important feature in those with type 2 diabetes. Integrative research is needed using behavioral, cognitive, imaging, and genetic platforms.
dc.description.sponsorshipCopyright Information: http://www.sherpa.ac.uk/romeo/search.php "Author can archive pre-print (ie pre-refereeing) … post-print (ie final draft post-refereeing) … [and] publisher's version/PDF … [on] non-commercial [sites]" - SHERPA/RoMEO site (as at 19/05/10)
dc.format4 pages
dc.publisherMedknow Publications
dc.rightshttp://www.sherpa.ac.uk/romeo/search.php "Author can archive pre-print (ie pre-refereeing) … post-print (ie final draft post-refereeing) … [and] publisher's version/PDF … [on] non-commercial [sites]" - SHERPA/RoMEO site (as at 19/05/10)
dc.sourceIndian Journal of Psychiatry
dc.source.urihttp://www.indianjpsychiatry.org/article.asp?issn=0019-5545;year=2009;volume=51;issue=5;spage=35;epage=38;aulast=Kumar
dc.subjectbrain atrophy
dc.subjectcognition
dc.subjectdiabetes mellitus
dc.subjectmagnetic resonance imaging
dc.subjectneurodegeneration
dc.titleType 2 diabetes mellitus, cognition and brain in aging: a brief review
dc.typeJournal article
local.description.notesThis is an invited article.
local.identifier.citationvolume51
dc.date.issued2009-01
local.identifier.absfor170102
local.identifier.ariespublicationa154704xPUB1
local.type.statusPublished Version
local.contributor.affiliationKumar, Rajeev, School of Health and Psychological Sciences, ANU Medical School
local.contributor.affiliationLooi, Jeffrey, School of Health and Psychological Sciences, ANU Medical School
local.contributor.affiliationRaphael, Beverley, School of Health and Psychological Sciences, ANU Medical School
local.bibliographicCitation.issueSupplement January 2009
local.bibliographicCitation.startpages35
local.bibliographicCitation.lastpage38
dc.date.updated2021-08-01T08:21:02Z
CollectionsANU Research Publications

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