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The replacement histone H2A.Z in a hyperacetylated form is a feature of active genes in the chicken

Bruce, Kimberley; Myers, Fiona; Mantouvalou, Evangelia; Lefevre, Pascal; Greaves, Ian; Bonifer, Constanze; Tremethick, David; Thorne, Alan W; Crane-Robinson, Colyn


The replacement histone H2A.Z is variously reported as being linked to gene expression and preventing the spread of heterochromatin in yeast, or concentrated at heterochromatin in mammals. To resolve this apparent dichotomy, affinity-purified antibodies against the N-terminal region of H2A.Z, in both a triacetylated and non-acetylated state, are used in native chromatin immmuno-precipitation experiments with mononucleosomes from three chicken cell types. The hyperacetylated species concentrates...[Show more]

CollectionsANU Research Publications
Date published: 2005-10-04
Type: Journal article
Source: Nucleic Acids Research
DOI: 10.1093/nar/gki874


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