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RRP20, a componenet of the 90S preribosome, is required for pre-18S rRNA processing in Saccharomyces cerevisiae

Senapin, S; Clark-Walker, George; Chen, Xin Jie; Seraphin, Bertrand; Daugeron, Marie-Claire


A strain of Saccharomyces cerevisiae, defective in small subunit ribosomal RNA processing, has a mutation in YOR145c ORF that converts Gly235 to Asp. Yor145c is a nucleolar protein required for cell viability and has been reported recently to be present in 90S pre-ribosomal particles. The Gly235Asp mutation in YOR145c is found in a KH-type RNA-binding domain and causes a marked deficiency in 18S rRNA production. Detailed studies by northern blotting and primer extension analyses show that the...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Nucleic Acids Research
DOI: 10.1093/nar/gkg366


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