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GM-CSF promoter chromatin remodelling and gene transcription display distinct signal and transcription factor requirements

Brettingham-Moore, Kate H; Rao, Sudha; Juelich, Torsten; Shannon, M Frances; Holloway, Adele F


Granulocyte-macrophage colony stimulating factor (GM-CSF) plays a key role in myeloid cell function and is rapidly and transiently expressed in T cells in response to immune or inflammatory stimuli. Induction of GM-CSF gene expression is accompanied by changes in chromatin structure across the proximal promoter region of the gene. We show that the promoter remodelling and subsequent gene transcription occurs with distinct signal and transcription factor requirements. Activation of the protein...[Show more]

CollectionsANU Research Publications
Date published: 2005-01-12
Type: Journal article
Source: Nucleic Acids Research
DOI: 10.1093/nar/gki161


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