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Determinants of a transcriptionally competent environment at the GM-CSF promoter

Brettingham-Moore, Kate H; Sprod, O R; Chen, Xinxin; Oakford, P; Shannon, M Frances; Holloway, Adele F


Granulocyte macrophage-colony stimulating factor (GM-CSF) is produced by T cells, but not B cells, in response to immune signals. GM-CSF gene activation in response to T-cell stimulation requires remodelling of chromatin associated with the gene promoter, and these changes do not occur in B cells. While the CpG methylation status of the murine GM-CSF promoter shows no correlation with the ability of the gene to respond to activation, we find that the basal chromatin environment of...[Show more]

CollectionsANU Research Publications
Date published: 2008-03-15
Type: Journal article
Source: Nucleic Acids Research
DOI: 10.1093/nar/gkn117


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