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Intranasal flu vaccine protective against seasonal and H5N1 avian influenza infections

Alsharifi, Mohammed; Furuya, Yoichi; Bowden, Timothy; Lobigs, Mario; Koskinen, Aulikki; Regner, Matthias; Trinidad, Lee; Boyle, David B; Mullbacher, Arno


BACKGROUND Influenza A (flu) virus causes significant morbidity and mortality worldwide, and current vaccines require annual updating to protect against the rapidly arising antigenic variations due to antigenic shift and drift. In fact, current subunit or split flu vaccines rely exclusively on antibody responses for protection and do not induce cytotoxic T (Tc) cell responses, which are broadly cross-reactive between virus strains. We have previously reported that γ-ray inactivated flu virus...[Show more]

CollectionsANU Research Publications
Date published: 2009-04-29
Type: Journal article
Source: PLOS ONE (Public Library of Science)
DOI: 10.1371/journal.pone.0005336


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