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The evolution of the DLK1-DIO3 imprinted domain in mammals

Edwards, Carol A; Mungall, Andrew J; Matthews, Lucy; Ryder, Edward; Gray, Dionne J; Pask, Andrew J; Shaw, Geoffrey; Graves, Jennifer; Rogers, Jane; Dunham, Ian; Renfree, Marilyn B; Ferguson-Smith, Anne C

Description

A comprehensive, domain-wide comparative analysis of genomic imprinting between mammals that imprint and those that do not can provide valuable information about how and why imprinting evolved. The imprinting status, DNA methylation, and genomic landscape of the Dlk1-Dio3 cluster were determined in eutherian, metatherian, and prototherian mammals including tammar wallaby and platypus. Imprinting across the whole domain evolved after the divergence of eutherian from marsupial mammals and in...[Show more]

dc.contributor.authorEdwards, Carol A
dc.contributor.authorMungall, Andrew J
dc.contributor.authorMatthews, Lucy
dc.contributor.authorRyder, Edward
dc.contributor.authorGray, Dionne J
dc.contributor.authorPask, Andrew J
dc.contributor.authorShaw, Geoffrey
dc.contributor.authorGraves, Jennifer
dc.contributor.authorRogers, Jane
dc.contributor.authorDunham, Ian
dc.contributor.authorRenfree, Marilyn B
dc.contributor.authorFerguson-Smith, Anne C
dc.date.accessioned2009-06-11T03:34:36Z
dc.date.accessioned2010-12-20T06:03:22Z
dc.date.available2009-06-11T03:34:36Z
dc.date.available2010-12-20T06:03:22Z
dc.identifier.citationPLoS Biology 6.6 (2008): e135
dc.identifier.issn1544-9173
dc.identifier.issn1545-7885
dc.identifier.urihttp://hdl.handle.net/10440/465
dc.identifier.urihttp://digitalcollections.anu.edu.au/handle/10440/465
dc.description.abstractA comprehensive, domain-wide comparative analysis of genomic imprinting between mammals that imprint and those that do not can provide valuable information about how and why imprinting evolved. The imprinting status, DNA methylation, and genomic landscape of the Dlk1-Dio3 cluster were determined in eutherian, metatherian, and prototherian mammals including tammar wallaby and platypus. Imprinting across the whole domain evolved after the divergence of eutherian from marsupial mammals and in eutherians is under strong purifying selection. The marsupial locus at 1.6 megabases, is double that of eutherians due to the accumulation of LINE repeats. Comparative sequence analysis of the domain in seven vertebrates determined evolutionary conserved regions common to particular sub-groups and to all vertebrates. The emergence of Dlk1-Dio3 imprinting in eutherians has occurred on the maternally inherited chromosome and is associated with region-specific resistance to expansion by repetitive elements and the local introduction of noncoding transcripts including microRNAs and C/D small nucleolar RNAs. A recent mammal-specific retrotransposition event led to the formation of a completely new gene only in the eutherian domain, which may have driven imprinting at the cluster.
dc.format14 pages
dc.publisherPublic Library of Science
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.sourcePLoS Biology
dc.source.urihttp://www.plosbiology.org/article/info%3Adoi%2F10.1371%2Fjournal.pbio.0060135
dc.subjectKeywords: DNA; gene product; microRNA; repetitive DNA; small nucleolar RNA; article; chromosome analysis; DIO3 gene; dlk1 gene; DNA methylation; DNA transposition; eutherian mammal; gene; gene cluster; genetic conservation; genome imprinting; mammal; metatherian ma
dc.titleThe evolution of the DLK1-DIO3 imprinted domain in mammals
dc.typeJournal article
local.identifier.citationvolume6
dcterms.dateAccepted2008-04-18
dc.date.issued2008-06-03
local.identifier.absfor060404 (50%), 060407 (50%)
local.identifier.ariespublicationu9204316xPUB538
local.type.statusPublished Version
local.contributor.affiliationEdwards, Carol A, University of Cambridge
local.contributor.affiliationMungall, Andrew J, Wellcome Trust Sanger Institute
local.contributor.affiliationMatthews, Lucy, Wellcome Trust Sanger Institute
local.contributor.affiliationRyder, Edward, University of Cambridge
local.contributor.affiliationGray, Dionne J, University of Cambridge
local.contributor.affiliationPask, Andrew J, University of Melbourne
local.contributor.affiliationShaw, Geoffrey, University of Melbourne
local.contributor.affiliationGraves, Jennifer, Research School of Biological Sciences, Comparative Genomics Research Group
local.contributor.affiliationRogers, Jane, Wellcome Trust Genome Campus
local.contributor.affiliationDunham, Ian, Wellcome Trust Sanger Institute
local.contributor.affiliationRenfree, Marilyn B, University of Melbourne
local.contributor.affiliationFerguson-Smith, Anne C, University of Cambridge
local.bibliographicCitation.issue6
local.bibliographicCitation.startpage1292
local.bibliographicCitation.lastpage1305
local.identifier.doi10.1371/journal.pbio.0060135
dc.date.updated2015-12-10T07:57:03Z
local.identifier.scopusID2-s2.0-45849118721
local.identifier.thomsonID000257105500016
CollectionsANU Research Publications

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