Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex
Belov, Katherine; Deakin, Janine; Papenfuss, Anthony T; Baker, Michelle L; Melman, Sandra D; Siddle, Hannah V; Gouin, Nicolas; Goode, David; Sargeant, Tobias; Robinson, Mark D; Wakefield, Matthew; Mahony, Shaun; Cross, Joe; Benos, Panayiotis; Samollow, Paul; Speed, Terence P; Graves, Jennifer; Miller, Robert D
The first sequenced marsupial genome promises to reveal unparalleled insights into mammalian evolution. We have used theMonodelphis domestica (gray short-tailed opossum) sequence to construct the first map of a marsupial major histocompatibility complex (MHC). The MHC is the most gene-dense region of the mammalian genome and is critical to immunity and reproductive success. The marsupial MHC bridges the phylogenetic gap between the complex MHC of eutherian mammals and the minimal essential MHC...[Show more]
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