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The evolution of epigenetic regulators CTCF and BORIS/CTCFL in amniotes

Hore, Tim; Deakin, Janine; Graves, Jennifer


CTCF is an essential, ubiquitously expressed DNA-binding protein responsible for insulator function, nuclear architecture, and transcriptional control within vertebrates. The gene CTCF was proposed to have duplicated in early mammals, giving rise to a paralogue called “brother of regulator of imprinted sites” (BORIS or CTCFL) with DNA binding capabilities similar to CTCF, but testis-specific expression in humans and mice. CTCF and BORIS have opposite regulatory effects on human cancer-testis...[Show more]

CollectionsANU Research Publications
Date published: 2008-08-25
Type: Journal article
Source: PLoS Genetics
DOI: 10.1371/journal.pgen.1000169


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