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Retrotransposon silencing by DNA methylation can drive mammalian genomic imprinting

Suzuki, Shunsuke; Ono, Ryuichi; Narita, Takanori; Pask, Andrew J; Shaw, Geoffrey; Wang, Changshan; Kohda, Takashi; Alsop, Amber; Graves, Jennifer; Kohara, Yuji; Ishino, Fumitoshi; Renfree, Marilyn B; Kaneko-Ishino, Tomoko


Among mammals, only eutherians and marsupials are viviparous and have genomic imprinting that leads to parent-of-origin-specific differential gene expression. We used comparative analysis to investigate the origin of genomic imprinting in mammals. PEG10 (paternally expressed 10) is a retrotransposon-derived imprinted gene that has an essential role for the formation of the placenta of the mouse. Here, we show that an orthologue of PEG10 exists in another therian mammal, the marsupial tammar...[Show more]

CollectionsANU Research Publications
Date published: 2007-04-13
Type: Journal article
Source: PLoS Genetics
DOI: 10.1371/journal.pgen.0030055


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