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Recent assembly of an imprinted domain from non-imprinted components

Rapkins, Robert; Hore, Tim; Smithwick, Megan; Ager, Eleanor; Pask, Andrew J; Renfree, Marilyn B; Kohn, Matthias; Hameister, Horst; Nicholls, Robert D; Deakin, Janine; Graves, Jennifer


Genomic imprinting, representing parent-specific expression of alleles at a locus, raises many questions about how—and especially why—epigenetic silencing of mammalian genes evolved. We present the first in-depth study of how a human imprinted domain evolved, analyzing a domain containing several imprinted genes that are involved in human disease. Using comparisons of orthologous genes in humans, marsupials, and the platypus, we discovered that the Prader-Willi/Angelman syndrome region on human...[Show more]

CollectionsANU Research Publications
Date published: 2006-10-27
Type: Journal article
Source: PLoS Genetics
DOI: 10.1371/journal.pgen.0020182


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