Study protocol: a randomised controlled trial of multiple and single dose activated charcoal for acute self-poisoning
Eddleston, Michael; Juszczak, Edmund; Buckley, Nicholas; Senarathna, Lalith; Mohammed, Fahim; Allen, Stuart; Dissanayake, Wasantha; Hittarage, Ariyasena; Azher, Shifa; Jeganathan, K; Jayamanne, Shaluka; Sheriff, M H Rezvi; Warrell, David
BACKGROUND: The case fatality for intentional self-poisoning in rural Asia is 10–30 times higher than in the West, mostly due to the use of highly toxic poisons. Activated charcoal is a widely available intervention that may – if given early – bind to poisons in the stomach and prevent their absorption. Current guidelines recommend giving a single dose of charcoal (SDAC) if patients arrive within an hour of ingestion. Multiple doses (MDAC) may increase poison elimination at a later time by...[Show more]
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|Source:||BMC Emergency Medicine|
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