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NAT Gene polymorphisms and susceptibility to Alzheimer's disease: identification of a novel NAT1 allelic variant

Johnson, Nichola; Bell, Peter; Jonovska, Vesna; Budge, Marc; Sim, E


BACKGROUND: Alzheimer's disease is multifactorial, having environmental, toxicological and genetic risk factors. Impaired folate and homocysteine metabolism has been hypothesised to increase risk. In addition to its xenobiotic-metabolising capacity, human arylamine N-acetyltransferase type-1 (NAT1) acetylates the folate catabolite para-aminobenzoylglutamate and is implicated in folate metabolism. The purpose of this study was to determine whether polymorphisms in the human NAT genes influence...[Show more]

CollectionsANU Research Publications
Date published: 2004-03-17
Type: Journal article
Source: BMC Medical Genetics
DOI: 10.1186/1471-2350-5-6


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