NAT Gene polymorphisms and susceptibility to Alzheimer's disease: identification of a novel NAT1 allelic variant
BACKGROUND: Alzheimer's disease is multifactorial, having environmental, toxicological and genetic risk factors. Impaired folate and homocysteine metabolism has been hypothesised to increase risk. In addition to its xenobiotic-metabolising capacity, human arylamine N-acetyltransferase type-1 (NAT1) acetylates the folate catabolite para-aminobenzoylglutamate and is implicated in folate metabolism. The purpose of this study was to determine whether polymorphisms in the human NAT genes influence...[Show more]
|Collections||ANU Research Publications|
|Source:||BMC Medical Genetics|
|Johnson_NAT2004.pdf||336.75 kB||Adobe PDF|
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