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The association of APOE genotype and cognitive decline in interaction with risk factors in a 65-69 year old community sample

Christensen, Helen; Batterham, Philip; Mackinnon, Andrew; Jorm, Anthony F; Mack, Holly; Mather, Karen; Anstey, Kaarin; Sachdev, Perminder Singh; Easteal, Simon


BACKGROUND: While the evidence of an association between the apolipoprotein E (APOE) *E4 allele and Alzheimer's disease is very strong, the effect of the *E4 allele on cognitive decline in the general population is more equivocal. A cross-sectional study on the lifespan effects of the *E4 allele [1] failed to find any effect of the *E4 allele on cognitive performance at ages 20–24, 40–44 or 60–64 years. METHODS: In this four year follow-up study, we reexamine the effect of *E4 in the...[Show more]

CollectionsANU Research Publications
Date published: 2008-07-14
Type: Journal article
Source: BMC geriatrics
DOI: 10.1186/1471-2318-8-14


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