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Vascular microarray profiling in two models of hypertension identifies caveolin-1, Rgs2 and Rgs5 as antihypertensive targets

Grayson, Hilton; Ohms, Stephen J; Brackenbury, Therese; Meaney, Kate; Peng, Kaimen; Pittelkow, Yvonne; Wilson, Susan; Sandow, Shaun L; Hill, Caryl


BACKGROUND: Hypertension is a complex disease with many contributory genetic and environmental factors. We aimed to identify common targets for therapy by gene expression profiling of a resistance artery taken from animals representing two different models of hypertension. We studied gene expression and morphology of a saphenous artery branch in normotensive WKY rats, spontaneously hypertensive rats (SHR) and adrenocorticotropic hormone (ACTH)-induced hypertensive rats. RESULTS:...[Show more]

CollectionsANU Research Publications
Date published: 2007-11-07
Type: Journal article
Source: BMC Genomics
DOI: 10.1186/1471-2164-8-404


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