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Origin and evolution of candidate mental retardation genes on the human X chromosome (MRX)

Delbridge, Margaret; McMillan, Daniel; Doherty, Ruth; Deakin, Janine; Graves, Jennifer


BACKGROUND: The human X chromosome has a biased gene content. One group of genes that is over-represented on the human X are those expressed in the brain, explaining the large number of sex-linked mental retardation (MRX) syndromes. RESULTS: To determine if MRX genes were recruited to the X, or whether their brain-specific functions were acquired after relocation to the mammalian X chromosome, we examined the location and expression of their orthologues in marsupials, which diverged from...[Show more]

CollectionsANU Research Publications
Date published: 2008-02-05
Type: Journal article
Source: BMC Genomics
DOI: 10.1186/1471-2164-9-65


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