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Evolution and comparative analysis of the MHC Class III inflammatory region

Deakin, Janine; Papenfuss, Anthony T; Belov, Katherine; Cross, Joe; Coggill, P; Palmer, Sophie; Sims, S; Speed, Terence P; Beck, Stephan; Graves, Jennifer


BACKGROUND: The Major Histocompatibility Complex (MHC) is essential for immune function. Historically, it has been subdivided into three regions (Class I, II, and III), but a cluster of functionally related genes within the Class III region has also been referred to as the Class IV region or "inflammatory region". This group of genes is involved in the inflammatory response, and includes members of the tumour necrosis family. Here we report the sequencing, annotation and comparative analysis...[Show more]

CollectionsANU Research Publications
Date published: 2006-11-02
Type: Journal article
Source: BMC Genomics
DOI: 10.1186/1471-2164-7-281


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