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Precision-mapping and statistical validation of quantitative trait loci by machine learning

Bedo, Justin; Wenzl, Peter; Kowalczyk, Adam; Kilian, Andrezej


BACKGROUND: We introduce a QTL-mapping algorithm based on Statistical Machine Learning (SML) that is conceptually quite different to existing methods as there is a strong focus on generalisation ability. Our approach combines ridge regression, recursive feature elimination, and estimation of generalisation performance and marker effects using bootstrap resampling. Model performance and marker effects are determined using independent testing samples (individuals), thus providing better...[Show more]

CollectionsANU Research Publications
Date published: 2008-05-02
Type: Journal article
Source: BMC Genetics
DOI: 10.1186/1471-2156-9-35


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