Skip navigation
Skip navigation

Precision-mapping and statistical validation of quantitative trait loci by machine learning

Bedo, Justin; Wenzl, Peter; Kowalczyk, Adam; Kilian, Andrezej

Description

BACKGROUND: We introduce a QTL-mapping algorithm based on Statistical Machine Learning (SML) that is conceptually quite different to existing methods as there is a strong focus on generalisation ability. Our approach combines ridge regression, recursive feature elimination, and estimation of generalisation performance and marker effects using bootstrap resampling. Model performance and marker effects are determined using independent testing samples (individuals), thus providing better...[Show more]

CollectionsANU Research Publications
Date published: 2008-05-02
Type: Journal article
URI: http://hdl.handle.net/10440/230
http://digitalcollections.anu.edu.au/handle/10440/230
Source: BMC Genetics
DOI: 10.1186/1471-2156-9-35

Download

File Description SizeFormat Image
Bedo_Precision2008.pdf594.52 kBAdobe PDFThumbnail


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  23 August 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator