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Glutathione s-transferase omega in the lung and sputum supernatants of COPD patients

Harju, Terttu H; Peltoniemi, Mirva J; Rytila, Paula H; Soini, Ylermi; Salmenkivi, Kaisa M; Board, Philip; Ruddock, Lloyd W; Kinnula, Vuokko L


BACKGROUND: The major contribution to oxidant related lung damage in COPD is from the oxidant/antioxidant imbalance and possibly impaired antioxidant defence. Glutathione (GSH) is one of the most important antioxidants in human lung and lung secretions, but the mechanisms participating in its homeostasis are partly unclear. Glutathione-S-transferase omega (GSTO) is a recently characterized cysteine containing enzyme with the capability to bind and release GSH in vitro. GSTO has not been...[Show more]

CollectionsANU Research Publications
Date published: 2007-07-06
Type: Journal article
Source: Respiratory research
DOI: 10.1186/1465-9921-8-48


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