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Pathological rate matrices: from primates to pathogens

Schranz, Harold; Easteal, Simon; Huttley, Gavin Austin; Yap, Von Bing; Knight, Rob


BACKGROUND: Continuous-time Markov models allow flexible, parametrically succinct descriptions of sequence divergence. Non-reversible forms of these models are more biologically realistic but are challenging to develop. The instantaneous rate matrices defined for these models are typically transformed into substitution probability matrices using a matrix exponentiation algorithm that employs eigendecomposition, but this algorithm has characteristic vulnerabilities that lead to significant...[Show more]

CollectionsANU Research Publications
Date published: 2008-12-19
Type: Journal article
Source: BMC Bioinformatics
DOI: 10.1186/1471-2105-9-550


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