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Platypus globin genes and flanking loci suggest a new insertional model for beta-globin evolution in birds and mammals

Patel, Vidushi; Deakin, Janine; Graves, Jennifer; Cooper, Steven; Fulton, Bob; Graves, Tina; Warren, Wesley; Wilson, Richard K

Description

BACKGROUND: Vertebrate alpha (α)- and beta (β)-globin gene families exemplify the way in which genomes evolve to produce functional complexity. From tandem duplication of a single globin locus, the α- and β-globin clusters expanded, and then were separated onto different chromosomes. The previous finding of a fossil β-globin gene (ω) in the marsupial α-cluster, however, suggested that duplication of the α-β cluster onto two chromosomes, followed by lineage-specific gene loss and duplication,...[Show more]

CollectionsANU Research Publications
Date published: 2008-07-25
Type: Journal article
URI: http://hdl.handle.net/10440/109
http://digitalcollections.anu.edu.au/handle/10440/109
Source: BMC Biology
DOI: 10.1186/1741-7007-6-34

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