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MHC-linked and un-linked class 1 genes in the wallaby

Siddle, Hannah V; Deakin, Janine; Coggill, P; Hart, Elizabeth; Cheng, Yuanyuan; Wong, Emily; Harrow, Jennifer; Beck, Stephan; Belov, Katherine


BACKGROUND: MHC class I antigens are encoded by a rapidly evolving gene family comprising classical and non-classical genes that are found in all vertebrates and involved in diverse immune functions. However, there is a fundamental difference between the organization of class I genes in mammals and non-mammals. Non-mammals have a single classical gene responsible for antigen presentation, which is linked to the antigen processing genes, including TAP. This organization allows co-evolution...[Show more]

CollectionsANU Research Publications
Date published: 2009-07-14
Type: Journal article
Source: BMC Genomics
DOI: 10.1186/1471-2164-10-310


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