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Bayesian DNA copy number analysis

Rancoita, P M V; Hutter, Marcus; Bertoni, Francesco; Kwee, Ivo


BACKGROUND: Some diseases, like tumors, can be related to chromosomal aberrations, leading to changes of DNA copy number. The copy number of an aberrant genome can be represented as a piecewise constant function, since it can exhibit regions of deletions or gains. Instead, in a healthy cell the copy number is two because we inherit one copy of each chromosome from each our parents. Bayesian Piecewise Constant Regression (BPCR) is a Bayesian regression method for data that are noisy...[Show more]

CollectionsANU Research Publications
Date published: 2009-01-08
Type: Journal article
Source: BMC Bioinformatics
DOI: 10.1186/1471-2105-10-10


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