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Pitfalls of the most commonly used models of context dependent substitution

Lindsay, Helen; Ying, Hua; Huttley, Gavin Austin; Yap, Von Bing


BACKGROUND: Neighboring nucleotides exert a striking influence on mutation, with the hypermutability of CpG dinucleotides in many genomes being an exemplar. Among the approaches employed to measure the relative importance of sequence neighbors on molecular evolution have been continuous-time Markov process models for substitutions that treat sequences as a series of independent tuples. The most widely used examples are the codon substitution models. We evaluated the suitability of derivatives...[Show more]

CollectionsANU Research Publications
Date published: 2008-12-16
Type: Journal article
Source: Biology Direct
DOI: 10.1186/1745-6150-3-52


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