The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution

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dc.contributor.authorElsik, Christine G.en
dc.contributor.authorTellam, Ross L.en
dc.contributor.authorWorley, Kim C.en
dc.contributor.authorGibbs, Richard A.en
dc.contributor.authorAbatepaulo, Antonio R. R.en
dc.contributor.authorAbbey, Colette A.en
dc.contributor.authorAdelson, David L.en
dc.contributor.authorAerts, Janen
dc.contributor.authorAhola, Virpien
dc.contributor.authorAlexander, Leeen
dc.contributor.authorAlioto, Tyleren
dc.contributor.authorAlmeida, Iassudara G.en
dc.contributor.authorAmadio, Ariel F.en
dc.contributor.authorAnatriello, Elenen
dc.contributor.authorAntonarakis, Stylianos E.en
dc.contributor.authorAnzola, Juan M.en
dc.contributor.authorAstashyn, Alexen
dc.contributor.authorBahadue, Suria M.en
dc.contributor.authorBaldwin, Cynthia L.en
dc.contributor.authorBarris, Wesen
dc.contributor.authorBaxter, Rebeccaen
dc.contributor.authorBell, Stephanie Nicoleen
dc.contributor.authorBennett, Anna K.en
dc.contributor.authorBennett, Gary L.en
dc.contributor.authorBiase, Fernando H.en
dc.contributor.authorBoldt, Clayton R.en
dc.contributor.authorBradley, Daniel G.en
dc.contributor.authorBrinkman, Fiona S. L.en
dc.contributor.authorBrinkmeyer-Langford, Candice L.en
dc.contributor.authorBrown, Wendy C.en
dc.contributor.authorBrownstein, Michael J.en
dc.contributor.authorBuhay, Christianen
dc.contributor.authorCaetano, Alexandre R.en
dc.contributor.authorCamara, Franciscoen
dc.contributor.authorCarroll, Jeffrey A.en
dc.contributor.authorCarvalho, Wanessa A.en
dc.contributor.authorCasey, Theresaen
dc.contributor.authorCervelatti, Elaine P.en
dc.contributor.authorChack, Josephen
dc.contributor.authorChacko, Elsaen
dc.contributor.authorChandrabose, Mimi M.en
dc.contributor.authorChen, Linen
dc.contributor.authorEyras, Eduardoen
dc.contributor.authorGarcia, Gustavo R.en
dc.contributor.authorGilbert, James G. R.en
dc.contributor.authorJones, Steven J. M.en
dc.contributor.authorMoore, Richarden
dc.contributor.authorTaylor, Jeremy F.en
dc.contributor.authorWard, Roberten
dc.contributor.authorWilliams, John L.en
dc.date.accessioned2025-05-25T17:24:55Z
dc.date.available2025-05-25T17:24:55Z
dc.date.issued2009-04-24en
dc.description.abstractTo understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.en
dc.description.sponsorshipFunded by the National Human Genome Research Institute (NHGRI U54 HG003273); the U.S. Department of Agriculture's Agricultural Research Service (USDA-ARS agreement no. 59-0790-3-196) and Cooperative State Research, Education, and Extension Service National Research Initiative (grant no. 2004-35216-14163); the state of Texas; Genome Canada through Genome British Columbia; the Alberta Science and Research Authority; the Commonwealth Scientific and Industrial Research Organization of Australia (CSIRO); Agritech Investments Ltd., Dairy Insight, Inc., and AgResearch Ltd., all of New Zealand; the Research Council of Norway; the Kleberg Foundation; and the National, Texas, and South Dakota Beef Check-off Funds. The master accession for this WGS sequencing project is AAFC03000000. The individual WGS sequences are AAFC03000001 to AAFC03131728, and the scaffold records are CM000177 to CM000206 (chromosomes) and DS490632 to DS495890 (unplaced scaffolds).en
dc.description.statusPeer-revieweden
dc.format.extent7en
dc.identifier.issn0036-8075en
dc.identifier.otherWOS:000265411200050en
dc.identifier.otherPubMed:19390049en
dc.identifier.otherORCID:/0000-0003-0793-6218/work/162948939en
dc.identifier.scopus77951621301en
dc.identifier.urihttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=anu_research_portal_plus2&SrcAuth=WosAPI&KeyUT=WOS:000265411200050&DestLinkType=FullRecord&DestApp=WOS_CPLen
dc.identifier.urihttps://hdl.handle.net/1885/733753305
dc.language.isoenen
dc.sourceScienceen
dc.subjectNeonatal fc-receptoren
dc.subjectGene-expressionen
dc.subjectBovineen
dc.subjectOrganizationen
dc.subjectInterferonen
dc.subjectFamilyen
dc.subjectRolesen
dc.subjectMapen
dc.titleThe Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolutionen
dc.typeJournal articleen
dspace.entity.typePublicationen
local.bibliographicCitation.lastpage528en
local.bibliographicCitation.startpage522en
local.contributor.affiliationElsik, Christine G.; Georgetown Universityen
local.contributor.affiliationTellam, Ross L.; CSIROen
local.contributor.affiliationWorley, Kim C.; Baylor College of Medicineen
local.contributor.affiliationChen, Lin; School of Demography, Research School of Social Sciences, ANU College of Arts & Social Sciences, The Australian National Universityen
local.contributor.affiliationEyras, Eduardo; Genome Sciences and Cancer Division, John Curtin School of Medical Research, ANU College of Science and Medicine, The Australian National Universityen
local.contributor.affiliationGarcia, Gustavo R.; Atomic and Molecular Physics Research, Research School of Physics, ANU College of Science and Medicine, The Australian National Universityen
local.contributor.affiliationGilbert, James G. R.; Advanced Instrumentation and Technology Centre, Research School of Astronomy & Astrophysics, ANU College of Science and Medicine, The Australian National Universityen
local.contributor.affiliationJones, Steven J. M.; School of Politics & International Relations, Research School of Social Sciences, ANU College of Arts & Social Sciences, The Australian National Universityen
local.contributor.affiliationMoore, Richard; School of Philosophy, Research School of Social Sciences, ANU College of Arts & Social Sciences, The Australian National Universityen
local.contributor.affiliationTaylor, Jeremy F.; Sch of Culture History & Lang, School of Culture, History & Language, ANU College of Asia & the Pacific, The Australian National Universityen
local.contributor.affiliationWard, Robert; Centre for Gravitational Astrophysics, ANU College of Science and Medicine, The Australian National Universityen
local.contributor.affiliationWilliams, John L.; Arndt-Corden Department of Economics, Crawford School of Public Policy, ANU College of Law, Governance and Policy, The Australian National Universityen
local.identifier.citationvolume324en
local.identifier.doi10.1126/science.1169588en
local.identifier.pure141d753b-f10c-41b7-8c8a-5ab88c597e7den
local.identifier.urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=anu_research_portal_plus2&SrcAuth=WosAPI&KeyUT=WOS:000265411200050&DestLinkType=FullRecord&DestApp=WOS_CPLen
local.identifier.urlhttps://www.scopus.com/pages/publications/77951621301en
local.type.statusPublisheden

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