Asymmetric aldol reactions using boron enolates
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Paterson, Ian
Doughty, Victoria A.
Florence, Gordon
Gerlach, Kai
McLeod, Malcolm D.
Scott, Jeremy P.
Trieselmann, Thomas
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Abstract
The chiral boron enolates 7-14 add to aldehydes with high levels of stereocontrol in a predictable sense. These enolates are designed specifically for the aldol-based construction of the highly oxygenated and stereochemically challenging structures found in polyketide natural products, as illustrated here by their application to the total synthesis of concanamycin F and discodermolide.
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ACS Symposium Series
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