Having your cake and eating it too – a new target for sporozoite-neutralising mAbs
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Kaczmarski, Joe A.
Jackson, Colin J.
Cockburn, Ian A.
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Abstract
Current malaria vaccines provide suboptimal, waning protection. Dacon et al. identify a protective post-translationally modified epitope on Plasmodium sporozoites that is absent from current vaccines. This discovery deepens our understanding of Plasmodium biology and may inform the development of improved vaccines and complementary prophylactic monoclonal antibodies.
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Trends in Parasitology
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