Delivery and controllable release of anti-sense DNA based on frame-guided assembly strategy

Abstract

Using nanoparticles to deliver antisense oligonucleotides is a fabulous way which can solve the difficulty of penetrating cell membrane on account of high molecular weight and high negative charges. Herein, we have reported a frame-guided assembly strategy to prepare drug delivery system for anti-sense DNA. The in vitro experiments demonstrated that the anti-sense oligonucleotides vesicles perform good cytotoxicity to the cancer cells by downregulation of the expression of anti-apoptotic Bcl-2 gene, finally resulting in the apoptosis. It is feasible that taking advantage of the programmable assembly process and good stability of the frame-guided assembly (FGA) systems, this strategy can deliver a wide variety of drugs. Show more