A pH-driven ring translocation switch against cancer cells
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Cheng, Qian
Yin, Hang
Rosas, Roselyne
Gigmes, Didier
Ouari, Olivier
Wang, Ruibing
Kermagoret, Anthony
Bardelang, David
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Abstract
A molecular switch built with cucurbit[7]uril and a 3-station viologen-phenylene-imidazole compound exhibited pH actuated ring translocation with high fatigue resistance (up to 102 cycles). The switch movement was harnessed toward selectively masking the toxicity of the viologen fragment at neutral pH near non-cancerous cells, while exposing it at acid pH near cancer cells.
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Chemical Communications
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