Cytotoxic Spiroepoxide Lactone and Its Putative Biosynthetic Precursor from Goniobranchus Splendidus
| dc.contributor.author | Forster, Louise C. | en |
| dc.contributor.author | Pierens, Gregory K. | en |
| dc.contributor.author | White, Andrew M. | en |
| dc.contributor.author | Cheney, Karen L. | en |
| dc.contributor.author | Dewapriya, Pradeep | en |
| dc.contributor.author | Capon, Robert J. | en |
| dc.contributor.author | Garson, Mary J. | en |
| dc.date.accessioned | 2026-01-01T15:41:19Z | |
| dc.date.available | 2026-01-01T15:41:19Z | |
| dc.date.issued | 2017-06-30 | en |
| dc.description.abstract | Epoxygoniolide-1 (1), possessing spiroepoxide lactone, enal, and masked dialdehyde functionalities, has been characterized from the conspicuously patterned mollusc Goniobranchus splendidus. Its relative configuration was investigated by spectroscopic analyses, molecular modeling, and density functional theory calculations. The biosynthesis of 1 may involve rearrangement of a diterpene framework, providing a precursor to cometabolite gonioline (2), followed by C-C bond cleavage (via Grob or P450 mechanism). Moderate cytotoxicity to NCIH-460, SW60, or HepG2 cancer cells was observed for norditerpene 1. | en |
| dc.description.status | Peer-reviewed | en |
| dc.format.extent | 6 | en |
| dc.identifier.other | ORCID:/0000-0002-9481-1079/work/167652633 | en |
| dc.identifier.scopus | 85028927382 | en |
| dc.identifier.uri | https://hdl.handle.net/1885/733801211 | |
| dc.language.iso | en | en |
| dc.rights | Publisher Copyright: © 2017 American Chemical Society. | en |
| dc.source | ACS Omega | en |
| dc.title | Cytotoxic Spiroepoxide Lactone and Its Putative Biosynthetic Precursor from Goniobranchus Splendidus | en |
| dc.type | Journal article | en |
| dspace.entity.type | Publication | en |
| local.bibliographicCitation.lastpage | 2677 | en |
| local.bibliographicCitation.startpage | 2672 | en |
| local.contributor.affiliation | Forster, Louise C.; University of Queensland | en |
| local.contributor.affiliation | Pierens, Gregory K.; University of Queensland | en |
| local.contributor.affiliation | White, Andrew M.; School of Biological Sciences | en |
| local.contributor.affiliation | Cheney, Karen L.; University of Queensland | en |
| local.contributor.affiliation | Dewapriya, Pradeep; University of Queensland | en |
| local.contributor.affiliation | Capon, Robert J.; University of Queensland | en |
| local.contributor.affiliation | Garson, Mary J.; University of Queensland | en |
| local.identifier.citationvolume | 2 | en |
| local.identifier.doi | 10.1021/acsomega.7b00641 | en |
| local.identifier.pure | d7964705-09d3-461a-a45e-68a38fac9f8a | en |
| local.identifier.url | https://www.scopus.com/pages/publications/85028927382 | en |
| local.type.status | Published | en |